Peptides for discrimination of prions

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C436S501000, C436S518000, C530S300000

Reexamination Certificate

active

07807386

ABSTRACT:
The aim of the present invention is to provide a non-intrusive way to isolate, concentrate and monitor the TSE disease-related pathogenic prion protein. The invention described several peptides and their ability to capture PrPScfrom brain homogenate of prion disease infected animal and human. These eight peptides do not capture cellular prion protein from individual with no prion disease.

REFERENCES:
patent: 7482172 (2009-01-01), Zheng
patent: 2002/0004586 (2002-01-01), Aguzzi
patent: WO/02/065133 (2002-08-01), None
Luo et al. Molecular modeling and deletion mutagenesis implicate the nuclear translocation sequence in structural integrity of fibroblast growth factor-1. J Biol Chem. 1996. 271(43): 26876-83.
Chon and Chaikof. Soluble heparin-binding peptides regulate chemokinesis and cell adhesive forces. Am J Physiol Cell Physiol. 280: C1394-C1402, 2001.

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