Peptides for antagonizing the effects of amyloid .beta.protein

Details Peptides for antagonizing the effects of amyloid .beta.protein Peptides for antagonizing the effects of amyloid .beta.protein

1993-09-29

1995-11-28

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

4 to 5 amino acid residues in defined sequence

A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

054709512

ABSTRACT:
Three non-amnestic and non-memory enhancing peptides, Asp Phe Phe Val Gly (SEQ ID NO: 1), Gln Phe Val Gly (SEQ ID NO: 2), and Ala Ile Phe Thr (SEQ ID NO: 3), that block the effects of .beta.-(12-28), a peptide homologous to amyloid .beta. protein (A.beta.) are disclosed. This invention relates to amelioration of amnesia and other neurotoxicitiy in Alzheimer disease (AD) caused by deposition of A.beta. and, therefore, relates to attenuation of the disease process and consequential improvement of the quality of life for individuals suffering from AD.

REFERENCES:
Cecil Textbook of Medicine, 19th Ed. eds. Wyngaarden/Smith/Bennett, 1992 pp. 2076-2077.

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