Peptides for altering bone resorption, angiogenesis and restenos

Details Peptides for altering bone resorption, angiogenesis and restenos Peptides for altering bone resorption, angiogenesis and restenos

1995-04-12

1998-12-15

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

514 11, 514 13, 514 14, 514 15, 514 16, 514 17, 530326, 530327, 530328, 530329, 530330, A61K 3808, C07K 706, C07K 707, C07K 754

Patent

active

058498656

ABSTRACT:
The present invention provides Arg-Gly-Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also provides methods of using the Arg-Gly-Asp peptides to alter .alpha..sub.v .beta..sub.3 integrin receptor-mediated binding of a cell such as an osteoclast, endothelial cell or smooth muscle cell to a matrix. The invention further provides methods for ameliorating the severity of a pathology characterized, in part, by an undesirable level of bone resorption, angiogenesis or restenosis in a subject.

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PCT Search Report (dated 9 Nov. 1995), International application No. PCT/US95/04741.

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