Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1995-05-05
1996-10-22
Weimar, Elizabeth C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
530345, 530350, 514 18, A61K 3806
Patent
active
055678041
ABSTRACT:
Compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl or (C.sub.3 -C.sub.7) cycloalkyl
R.sub.2 represents alkyl, or (C.sub.3 -C.sub.7) cycloalkyl,
R.sub.3 represents hydrogen or alkyl,
R.sub.4 represents halogen or alkyl or alkoxy,
R.sub.5 represents alkyl,
X and Y, which are different, represent CO or SO.sub.2,
n represents 1, 2 or 3,
p represents 0 or 1,
Z represents sulfur or oxygen,
A represents any one of the following groups: ##STR2## in which: A.sub.1 represents, with the nitrogen and carbon atoms to which it is attached, a mono- or bicyclic heterocycle,
.cndot. or, ##STR3## in which: R.sub.6 represents hydrogen, alkyl or cycloalkyl or 2-indanyl,
R.sub.7 represents hydrogen or alkyl,
which compounds of formula (I) comprise thereof corresponding hydrates of the ketone function COCF.sub.3,
the enantiomers, diastereoisomers and epimers thereof and the addition salts thereof with a pharmaceutically acceptable base and medical products containing the same are useful as HLE inhibitor.
REFERENCES:
patent: 5296591 (1994-03-01), Hemmi et al.
patent: 5430025 (1995-07-01), Hemmi et al.
Canet Emmanuel
De Nanteuil Guillaume
Portevin Bernard
Adir et Compagnie
Gupta Anish
Weimar Elizabeth C.
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