Peptides derived from the pS2 protein

Details Peptides derived from the pS2 protein Peptides derived from the pS2 protein

1992-12-10

1997-06-03

Sidberry, Hazel F.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530300, 530325, 5303888, 53038885, A61K 3800, C07K 1400, C07K 1600, C07K 1630

Patent

active

056355963

ABSTRACT:
Peptides derived from the pS2 protein and polyclonal and monoclonal antibodies directed against pS2 and against pS2 fragments. Method of obtaining the secreted from of the pS2 protein and fragments thereof. Method of detecting and diagnosing different pathological conditions and especially hormone-dependent breast cancers and pathological conditions of the stomach.

REFERENCES:
patent: 5202417 (1993-04-01), Hayashi
von Heijne Eur J Biochem 133 1983 pp. 17-21 Patterns of Amino Acids Near Signal-Sequence Cleavage Sites.
Cloning of a Gene Expressed in Human-Breast Cancer and Regulation By Estrogen In MCF-7 Cell pp. 11-21 Prud'Homme et. DNA 1985 vol. 4.
Mairesse et al Biochem & Bioph. Res Com vol. 97 1980, pp. 1251-1257--Estrogen-Induced Protein In the Human Breast Cancer Cell Line MCF-7.
Sofer Biotechniques. vol. 1 pp. 198-203 1983 Designing an Optimal Chromatographic Purification Scheme for Proteins.
Scopes--Protein Purification & Practice, Springer-Verlag pp. 55-62 1980.
Nucleic Acids Research, vol. 15, No. 4, Feb. 25, 1987, IRL Press, Oxford-Washington DC, J.J. Jeltsch et al.: "Structure of the Human Oestrogen-Responsive Gene pS2", pp. 1401-1414.
Science, vol. 241, Aug. 5, 1988, M.C. Rio et al.: "Breast Cancer--Associated pS2 Protein: Synthesis and Secretion By Normal Stomach Mucosa", pp. 705-708.
Annals of the New York Academy of Sciences, vol. 464, 1986, The New York Academy of Sciences, B. Gairard et al.: "Estrogen-Inducible Gene In Human Breast Cancer", pp. 443-447.
Perlman et al, J Mol. Biol 167: 391-409, "A Putative Signal Peptidase Recognition Site & Sequence in Eukaryotic & Prokaryotic Signal Peptides".
Lerner et al, The Biology of Immunologic Disease pp. 331-338, 1983 The Development of Synthetic Vaccines, Chapter 31.
Brown et al, PNAS 81: 6344-6348, 1984, "Activation of Ps2 Gene Transcription Is a Primary Response to Estrogen In the Human Breast Cancer Cell Line MCF-7".
Jakowlew et al NAR 12: 2861-2878, "Sequence of the Ps2 In RNA Induced By Estrogen In the Breast Cancer Cell Line MCF-7".
Nunez et al, Endocrinology, 121: 1759-1765 Nov. 1987 "Characterization of the Estrogen-Induced pS2 Protein Secreted By the Human Breast Cancer Cell Line MCF-7."
Mori et al, Biochem. & Biophys. Res Comm. 155: 366-372 Aug. 1988, "Identification of a Polypeptide Secreted By Human Breast Cancer Cells (MCF-7) As the Human Estrogen-Responsive Gene (pS2) Product."

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