Peptides derived from the protein MMP-2, and the use thereof...

Details Peptides derived from the protein MMP-2, and the use thereof... Peptides derived from the protein MMP-2, and the use thereof...

2004-06-24

2009-12-08

Rawlings, Stephen L (Department: 1643)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

C530S327000, C530S350000

Reexamination Certificate

active

07629439

ABSTRACT:
Peptides derived from MMP-2 metalloproteinase that form T cell epitopes when presented by MHC Class I molecules. Anti-tumor therapy using these peptides.

REFERENCES:
patent: 5763219 (1998-06-01), Keyomarsi
patent: 6500924 (2002-12-01), Brooks et al.
patent: 97/45137 (1997-12-01), None
patent: 01/80811 (2001-11-01), None
patent: 02/098351 (2002-12-01), None
Elgert et al (Immunology: Understanding the Immune System, 1996, pp. 143-145).
Brooks, Peter C. et al., “Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity”, Cell, Cell Press, vol. 92, pp. 391-400, 1998.
Massova, Irina et al, “Matrix metalloproteinases: structures, evolution, and diversification”, FASEB Journal, vol. 12, pp. 1075-1095, , 1998.
Egeblad, Mikala et al., “New functions for the matrix metalloproteinases in cancer progression”, Nature Reviews Cancer, vol. 2, No. 3, pp. 161-174, 2002.

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