Peptides derived from the human amyloid precursor protein

Details Peptides derived from the human amyloid precursor protein Peptides derived from the human amyloid precursor protein

2006-04-25

2006-04-25

Hayes, Robert C. (Department: 1649)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S326000

Reexamination Certificate

active

07034000

ABSTRACT:
The present invention is directed to certain peptides that correspond to sequence elements within the human Alzheimer's amyloid precursor protein (APP). These peptides may be used to protect cells from iron catalyzed oxidative damage.

REFERENCES:
patent: WO 99/58564 (1999-11-01), None
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Kang, et al., “The Precursor of Alzheimer's Disease Amyloid A4 Protein Resembles a Cell-Surface Receptor.”Nature325:733-736 (1987).
Lawson, et al., “Solving the Structure of Human H Ferritin by Genetically Engineering Intermolecular Crystal Contacts.”Nature349:541-544 (1991).
Jin, et al., “Peptides Containing the RERMS Sequence of Amyloid β/A4 Protein Precursor Bind Cell Surface and Promote Neurite Extension.”J. Neurosci. 14:5461-5470 (1994).
Rogers, et al., “Iron Oxidation and Neuroprotection by Secreted Amyloid Precursor Protein.”Soc. for Neurosci. Abstracts27:27 (2001).
Yamamoto, et al., “The Survival of Rat Cerebral Cortical Neurons in the Presence of Trophic APP Peptides.”J. Neurobiology25:585-594 (1994).

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