Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2005-05-03
2005-05-03
Nickol, Gary B. (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C424S184100, C424S130100, C435S007230
Reexamination Certificate
active
06887975
ABSTRACT:
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (serpentine transmembrane antigens of the prostate). Four particular human STEAPs are described and characterized herein. The human STEAPs exhibit a high degree of structural conservation among them but show no significant structural homology to any known human proteins. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1is highly over-expressed in certain other human cancers.
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Afar Daniel E.
Hubert Rene S.
Leong Kahan
Mitchell Stephen Chappell
Raitano Arthur B.
Agensys, Inc.
Morrison & Foerster / LLP
Nickol Gary B.
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