Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1993-12-21
1998-01-06
Schwadron, Ronald B.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
514 2, 514 12, 514 13, 514 14, 530324, 530327, 530350, 530395, 530326, 530325, 530345, 530402, 530403, 530806, 4241841, 4241851, 4241931, 42419511, 4241981, C07K 14705, C07K 1475, C07K 1447, A61K 3816
Patent
active
057056064
ABSTRACT:
The present invention provides oligopeptides corresponding to regions of the GPIIIa protein, which are capable of specifically binding aggregation mediators, such as fibrinogen. The oligopeptides will typically comprise at least about 5 to 20 amino acids, and are thus non-immunogenic and easy to produce, formulate and administer.
REFERENCES:
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4766073 (1988-08-01), Murray et al.
patent: 4889919 (1989-12-01), Murray et al.
patent: 5149780 (1992-09-01), Plow et al.
R. Pytela, M.D. Pierschbacher, M.H. Ginsberg, E.F. Plow, E. Ruoslahti, Science (1986), 231:1559, Platelet membrane glycoprotein I Ib/IIIa: Member of a family of Arg-Gly-Asp-specific adhesion receptors.
E.F. Plow, A.H. Srouji, D. Meyer, G. Marguerie, M.H. Ginsberg, J. Biol. Chem. (1984), 259:5388, Evidence that three adhesive proteins interact with a common recognition site on activated platelets.
M.D. Pierschbacher, E.G. Hagman, E. Ruoslahti, Cell (1981), 26:259, Location of the cell attachment and proteolytic fragments of the molecule.
M.D. Pierschbacher, E. Ruoslahti, Nature (1984), 309:30, Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule.
K.M. Yamada, D.W. Kennedy, J. Cell Biol (1984) 99:29, Dualistic nature of adhesive protein function: Fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function.
E. Ruoslahti, M.D. Pierschbacher, Science (1987), 238:491, New perspectives in cell adhesion: RGD and integrins.
M.E. Humphries, K. Olden, K.M. Yamada, Science (1986) 233:467, A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells.
E.F. Plow, M.D. Pierschbacher, E. Ruoslahti, G. Marguerie, M.H. Ginsberg, Proc. Natl. Acad. Sci USA (1985), 82:8057, The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.
S. Timmons, M. Kloczewiak, J. Hawiger, Proc. Natl. Acad. Sci USA (1984) 81:4935, ADP-dependent common receptor mechanism for binding of von Willebrand factor and fibrinogen to human platelets.
S.C. Lam, E.F. Plow, M.A. Smith, A. Andrieux, J-J Ryckwaert, G. Marguerie, M.H. Ginsberg, J. Biol. Chem. (1987) 262:947, Evidence that Arginyl-Glycyl-Aspartate peptides and fibrinogen .gamma. chain peptides share a common binding site on platelets.
M. Ginsberg, M.D. Pierschbacher, E. Ruoslahti, G. Marguerie, E.F. Plow, J. Biol. Chem. (1985) 260:3931, Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion.
T. K. Gartner and J. S. Bennett, J. Biol. Chem. (1985), 260:11891-11894, The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggragation and fibrinogen binding to activated platelets.
D. Phillips, I. Charo, L. Parise, and L. Fitzgerald, Blood (1988), 71:831-843, The platelet membrane glycoprotein IIb-IIIa complex.
J. Calvete, G. Rivas, M. Maruri, M. Alvarez, J. McGregor, C. Hew, and J. Gonzalez-Rodriguez, J. Biol. Chem. (1988), 250:697-704, Tryptic digestion of human GPIIIa.
I. Charo, L. Bekeart, and D. Phillips, J. Biol. Chem. (1987), 262:9935-9938, Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachments to adhesive proteins and the extracellular matrix.
L. Parise, S. Helgerson, B. Steiner, L. Nannizzi, and D. Phillips, J. Biol. Chem. (1987), 262:12597-12602, Synthetic peptides derived from fibrinogen and fibronectin change the conformation of purified platelet glycoprotein IIb-IIIa.
A. Nurden, J. George, and D. Phillips, Biochemistry of Platelets (1986), Academic Press, pp. 159-223, Platelet membrane glycoproteins: Their structure, function, and modification in disease.
L. Fitzgerald, B. Steiner, S. Rall, Jr., S. Lo, and D. Phillips, J. Biol. Chem. (1987), 262:3936-3939, Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone.
M. Koczewiak, S. Timmons, T. Lukas, and J. Hawiger, Biochemistry (1984), 23:1767, Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the .gamma. chain.
A. Hiraiwa, A. Matsukage, H. Shiku, T. Takahashi, K. Naito, and K. Yamada, Blood (1987), 69:560-564, Purification and partial amino acid sequence of human platelet membrane glycoproteins IIb and IIIa.
D. Haverstick, J. Cowan, K. Yamada, and S. A. Santoro, Blood (1985), 66:946-952, Inhibition of platelet adhesion to fibronectin, fibrinogen and von Willebrand factor substrates by a synthetic tetrapeptide derived fo rm the cell-binding domain of fibronectin.
R. Dalla Favera, E.P. Gelmann, R.C. Gallo and F. Wong-Staal, Nature (Jul. 2, 1981) 292:31-35, A human onc gene homologous to the transforming gene (v-sis) of a simian sarcoma virus.
S.G. Devare, E. P. Reddy, K.C. Robbins, P.R. Andersen, S. R. Tronick and S. A. Aaronson, Proc. Natl. Acad. Sci. USA (May 1982) 79:3179-3182. Nucleotide sequence of the transforming gene of simian sarcoma virus.
K. Glenn, D. F. Bowen-Pope, and Russell Ross, J. Biol. Chem. (May 10, 1982) 257:5172-5176, Platelet-derived growth factor. III. Identification of a platelet-derived growth factor receptor by affinity labeling.
S.F. Josephs, R.D. Favera, E.P. Gelmann, R.C. Gallo, F. Wong-Staal, Science (1983) 219:503-505, 5' viral and human cellular sequence corresponding to the transforming gene of simian sarcoma virus.
H. N. Antoniades and M. W. Hunkapiller, Science (1983) 220:963-965, Human platelet derived growth factor (PDGF): Amino-terminal amino acid sequence.
M. Waterfield, G.T. Scrace, N. Whittle, P. Stoobant, A. Johnsson, A. Wateson, B. Westermark, C.H. Heldin, J.S. Huang and T. F. Deuel, Nature (Jul. 7, 1983) 304:35-39, Platelet-derived growth factor is structurally related to the putative transforming protein p28.sup.sis of simian sarcoma virus.
R.F. Doolittle, et al., Science (Jul. 15, 1983) 221:275-276, Simian sarcoma virus onc gene, v-sis is derived from the gene (or genes) encoding a platelet-derived growth factor.
T.F. Deuel, J. S. Huang, S.S. Huang, P. Stroobant, M.D. Waterfield, Science (1983) 221:1348-1350, Expression of a platelet-derived growth factor-like protein in simian sarcoma virus transformed cells.
K.C. Robbins, H.N. Antoniades, S.G. Devare, M.W. Hunkapiller and S.A. Aaronson, (Oct. 13, 1983) Nature 305:605-608, Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor.
S.F. Josephs, C. Guo, L. Ratner, F. Wong-Staal, (Feb. 3, 1984) Science 223:487-491, Human protooncogene nucleotide sequences corresponding to the transforming region of simian sarcoma virus.
S.F. Josephs, L. Ratner, M.F. Clarke, E.H. Westin, M.S. Reitz, F. Wong-Staal, Science (1984) 225:636-639, Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.
C. Betsholz, A. Johnsson, C.H. Heldin, B. Westermark, P. Lind, M.S. Urdea, R. Eddy, T.B. Shows, K. Philpott, A.L. Mellor, T.J. Knott and J. Scott, Nature (1986) 320:695-699, cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumor cell lines.
I. Charo, L. Fitzgerald, B. Steiner, S. Rall, L. Bekeart and D. Phillips, Proc. Natl. Acad. Sci. USA (1986) 83:8351-8355, Platelet glycoproteins IIb and IIIa: Evidence for a family of immunologically and structurally related glycoproteins in mammalian cells.
E. Plow, J. Loftus, E. Levin, D. Fair, D. Dixon, J. Forsyth and M. Ginsberg, Proc. Natl. Acad. Sci. USA (1986) 83:6002-6006, Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells.
C. Cierniewski, S. Niewiarowski, D. Hershock, B. Rucinski and A. Schmaier, Biochim. Biophys. Acta (1987) 924:216-224, Quantitation and characterization of human platelet glycoprotein IIIa by radioimmunoassay.
Merck Manual, 11th ed. (1966) p. 1318.
Foon, Cancer Res., 49: 1621-39, 1989.
Edgington, Bio/Technology, 10: 383-386, 388, 389, 1992.
Charo et al., J. Biol Chem., 266:1415-21, 1991.
Charo Israel F.
Fitzgerald Laurence A.
Phillips David R.
COR Therapeutics Inc.
Schwadron Ronald B.
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