Peptides derived from foot-and-mouth disease virus, pharmaceutic

Details Peptides derived from foot-and-mouth disease virus, pharmaceutic Peptides derived from foot-and-mouth disease virus, pharmaceutic

1992-07-28

1999-01-26

Eisenschenk, Frank C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530328, 530329, 530330, 530350, 530806, 530826, 4241861, C07K 1409, A61K 39135

Patent

active

058640088

ABSTRACT:
A peptide and veterinarily acceptable salts thereof are disclosed which comprise an amino acid sequence which is derived from foot-and-mouth disease virus (FMDV). The peptide is independent within the FMDV structure of a B-cell epitode and is capable of eliciting T-cell help in an animal susceptible to FMDV infection for production of antibody against an antigen. Optionally, an amino acid in the sequence may be replaced by another amino acid which does not affect the function of the sequence to elicit T-cell help.

REFERENCES:
patent: 4544500 (1985-10-01), Bittle et al.
patent: 4558033 (1985-12-01), Rudman
patent: 4591552 (1986-05-01), Neurath
patent: 4605512 (1986-08-01), Schaller et al.
patent: 4732971 (1988-03-01), Dimarchi et al.
patent: 4743554 (1988-05-01), Boothroyd et al.
Rudinger, Peptide Hormones, Parsons (Ed.) U Park Press, Baltimore, pp. 1-7 (1976).
Surovoi et al., Bioorg. Khim. 14(10), pp. 1352-1362 (Chem. Abstr. CA110, No. 93126y) 1988.
Francis et al., Nature, vol. 330, pp. 168-170 (Nov. 12, 1987).

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