Peptides corresponding to membrane-bound IgA

Details Peptides corresponding to membrane-bound IgA Peptides corresponding to membrane-bound IgA

1993-04-30

1994-05-10

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530350, 530300, 530861, C07K 700

Patent

active

053108752

ABSTRACT:
The invention relates to a method of stimulating IgA production through administering a peptide which has the sequence of epitopes which are present on B cell-bound but not secreted IgA. This induces production of the antibody itself. These extracellular peptide segments form, entirely or in part, antigenic epitopes unique to membrane-bound but not secreted IgA.

REFERENCES:
patent: 4636463 (1987-01-01), Altman et al.
patent: 5091313 (1992-02-01), Chang
Word et al. The Murine Immunoglobulin & Gene . . . 1983. EMBO 2(6): 887-898.
Sitia et al. Membrane Bound and Secreted IgA 1982. J. of Immunol. 128(2): 712-716.
Cunningham et al. The Complete Amino Acid Sequence of B.sub.2 . . . 1973. Biochemistry 12(24): 4811.

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