Peptides containing the 18 to 23 residues of vasoactive intestin

Details Peptides containing the 18 to 23 residues of vasoactive intestin Peptides containing the 18 to 23 residues of vasoactive intestin

1986-10-17

1989-09-12

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514925, 530328, 530329, A61K 3702, C07K 706

Patent

active

048660396

ABSTRACT:
Peptides comprising, in sequence, units selected from the amino acid residues 17 to 24 of VIP, and consisting at least of the amino acid residues 18 to 23, or an analogue thereof wherein one or more of the amino acid residues is replaced by an equivalent other amino acid; having anti-ulcer activity, a process for their preparation and their use as pharmaceuticals.

REFERENCES:
patent: 4237046 (1980-12-01), Bodanszky
Lehninger et al. Biochemistry, Worth Publishers, Inc., pp. 71-75 (New York, 1975).
Rudinger, Peptide Hormone, Parsons (ed)., U. Park Press, Baltimore (1976).
Robberecht et al., Gut Hormones, 101, pp. 97-103 (1978).
Chemical Abstracts, vol. 102, 1985, p. 65, abstract No. 675y.
Chemical Abstracts, vol. 100, 1984, p. 675, abstract No. 175257z.
A. Couvineau et al., "Structural Requirements For VIP Interaction With Specific Receptors in Human and Rat Intestinal Membranes: Effect of Nine Partial Sequences," Biochemical and Biophysical Research Communications, 121, pp. 493-498 (1984).
M. Bodanszky et al., "A Preferred Conformation in the Vasoactive Intestinal Peptide (VIP), Molecular Architecture of Gastrointestinal Hormones," Bioorganic Chemistry, 3, pp. 133-140 (1974).

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