Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Lutenizing hormone releasing factor ; related peptides
Patent
1985-02-22
1987-06-30
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Lutenizing hormone releasing factor ; related peptides
C07K 720
Patent
active
046771930
ABSTRACT:
GnRH peptide analogs which regulate the secretion of gonadotropins by the pituitary gland and either promote or inhibit the release of steroids by the gonads. Administration of an effective amount of a GnRH antagonist prevents ovulation of female mammalian eggs and/or the release of gonadotropins. Administration of GnRH agonists can be used to regulate fertility in male and female mammals.
These and other peptide hormones exhibit improved binding efficiency and biological potency as a result having a residue in a critical, generally central location in the chain which residue contains a mixed alkyl ketone side-chain terminating in an aromatic group. Methods for efficiently synthesizing these peptides from readily available compounds are disclosed.
REFERENCES:
patent: 4118483 (1978-10-01), Konig et al.
George A. Olah, "Friedel-Crafts & Related Reactions", 1963, pp. 189-191, 317-323.
"The Peptides", 1980, vol. 2, Chap. 1, Barany et al., pp. 192-198.
von Walter Keller-Schierlein et al., Helvetica Chemica Acta, vol. 63, Fasc. 1, 1980, pp. 250-254.
Anderson Harry A.
Rivier Jean E. F.
Vale, Jr. Wylie W.
Phillips Delbert R.
The Salk Institute for Biological Studies
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