Peptides carrying substances across the blood brain barrier

Details Peptides carrying substances across the blood brain barrier Peptides carrying substances across the blood brain barrier

1999-11-26

2008-07-15

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S013800, C424S009100, C530S326000, C530S328000, C435S325000

Reexamination Certificate

active

07399747

ABSTRACT:
The invention concerns the use of a linear peptide paired with an active substance for diagnosing or treating a CNS pathology by preparing a medicine capable of crossing the blood brain barrier to be used for diagnosis or treatment of a pathology localized in the CNS.

REFERENCES:
patent: WO-97/12912 (1997-04-01), None
patent: WO-99/07728 (1999-02-01), None
Derossi et al., J. Biol. Chem. 269 (14), 10444-50 (1994).
Rousselle, C., et al., “New Advances in the Transport of Doxorubicin Through The Blood-Brain-Barrier by a Peptide Vector-Mediated Strategy”, Mol. Pharamacol., 57, 679 (2000), abstract only.
Rousselle, C., et al., “Enhanced Delivery of Doxorubicin into the Brain Via a Peptide-Vector-Mediated Strategy: Saturation Kinetics and Specificity”, J. Pharmacol. Exp Ther., 296, 124 (2001), abstract only.
Blanc, E., et al., “Peptide-Vector Strategy Bypasses P-Glycoprotein Efflux, and Enhances Brain Transport and Solubility of Paclitaxel”, Anticancer Drugs., 15, 947-954 (2004).
Rousselle, C., et al., “Improved Brain Delivery of Benzylpenicillin with a Peptide-Vector-Mediated Strategy”, J Drug Target., 10, 309-315 (2002).
Temsamani, J., et al., “Improved Brain Uptake and Pharmacological Activity Profile of Morphine-6-Glucuronide Using a Peptide Vector-Mediated Strategy”, J Pharmacol. Exp Ther., 313, 712, (2005), abstract only.
Rousselle, C., et al., “Improved Brain Uptake and Pharmacological Activity of Dalargin Using a Peptide-Vector Mediated Strategy”, J Pharmacol. Exp Ther., 306, 371 (2003), abstract only.
Guidance for Industry, “Estimating the Maxiimum Safe Starting Dose in initial Clinical Trials for Therapeutics in Adult Healthy Volunters” US Dept. Health and Human Services, Jul. 2005, Pharmacology and Toxicology, Internet accessalbe at http://www.fda.gov/cder/guidance/index.htm.

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