Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-07-10
2007-07-10
Romeo, David (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200, C514S013800, C514S014800, C514S016700, C514S801000, C424S426000, C530S326000, C530S327000, C530S329000, C530S330000, C530S350000
Reexamination Certificate
active
10639396
ABSTRACT:
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2.
REFERENCES:
patent: 4877864 (1989-10-01), Wang et al.
patent: 5013649 (1991-05-01), Wang et al.
patent: 5106748 (1992-04-01), Wozney et al.
patent: 5108922 (1992-04-01), Wang et al.
patent: 5116738 (1992-05-01), Wang et al.
patent: 5141905 (1992-08-01), Rosen et al.
patent: 5187076 (1993-02-01), Wozney et al.
patent: 5413914 (1995-05-01), Franzusoff
patent: 5635375 (1997-06-01), Kraus et al.
patent: 5637480 (1997-06-01), Celeste et al.
patent: 5639638 (1997-06-01), Wozney et al.
patent: 5658882 (1997-08-01), Celeste et al.
patent: 5661007 (1997-08-01), Wozney et al.
patent: 5688678 (1997-11-01), Hewick et al.
patent: 5756457 (1998-05-01), Wang et al.
patent: 5922846 (1999-07-01), Cerletti et al.
Rathore et al. N-terminal isoforms of recombinant human bone morphogenetic protein (rhBMP-2) are active in vitro and in vivo. Protein Sci. 4[Suppl.2], 443S (1995).
Groppe et al. Biochemical and biophysical characterization of refolded Drosophila DDP, a homolog of bone morphogenetic proteins 2 and 4. J Biol Chem. Oct. 30, 1998;273(44):290052-65.
Ebendal et al. 1998,J. Neurosci. 51:139.
Reddi, 1998,Nat. Biotechnol. 16:247.
Wozney, 1989,Prog. Growth Factor Res. 1(1):267.
International Search Report for PCT/US03/25177, mailed Oct. 26, 2004.
Nichols Pilarin E.L.
Perez-Ramirez Bernardo
Finnegan Henderson Farabow Garrett & Dunner LLP
Romeo David
Wyeth
LandOfFree
Peptides as solubilizing excipients for transforming growth... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptides as solubilizing excipients for transforming growth..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides as solubilizing excipients for transforming growth... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3813577