Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence
Reexamination Certificate
2008-04-29
2008-04-29
Haddad, Maher M. (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
11 to 14 amino acid residues in defined sequence
Reexamination Certificate
active
10873848
ABSTRACT:
The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having demonstrated anti-tumor activity. The claimed peptide represents a conformational epitope or mimotope present on the ligand to which the therapeutic antibodies selectively bind.
REFERENCES:
patent: 2003/6040044 (2003-02-01), Giles-Komar
patent: 2004/0185507 (2004-09-01), Giles-Komar
patent: 2343602 (2001-10-01), None
patent: WO 0212501 (2002-02-01), None
patent: WO 02/31510 (2002-04-01), None
Van Regenmortel MHV. Mapping Epitope Structure and Activity: From One-Dimensional Prediction to Four-Dimensional Description of Antigenic Specificity Methods. 9(3):465-72, 1996.
Reineke et al, “A synthetic mimic of a discontinuous binding site on interleukin-10”,Nature Biotechnology., 1999, pp. 271-275, vol. 17.
Birkenmeier et al, “Epitope mapping by screening of phage display libraries of a monoclonal antibody directed against the receptor binding domain of human alpha2-macroglobulin,” FEBS lett. Oct. 20, 1997, vol. 416, No. 2, pp. 193-196.
Byun et al, Identification of the peptides that inhibit the function of human monoclonal thyroid-stimulating antibodies from phage-displayed peptide library. J. Clin Endocrinol Metaab. 2001. vol. 86, No. 7, pp. 33′11-3318.
Al-Bukhari et al, “An immuno-precipitation assay for determining specific interactions between antibodies and phage selected from random peptide expression libraries,” J. Immunol. Methods, Jun. 1, 2002, Vo. 264, No. 1-2, pp. 163-171.
Baker Audrey
Chen Yan
Shealy David
Wu Sam
Centocor, Inc.
Dow Kenneth J.
Haddad Maher M.
LandOfFree
Peptides antagonistic to an anti-angiogenic antibody and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptides antagonistic to an anti-angiogenic antibody and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides antagonistic to an anti-angiogenic antibody and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3932233