Peptides and their use as inhibitors of hepatitis C virus...

Details Peptides and their use as inhibitors of hepatitis C virus... Peptides and their use as inhibitors of hepatitis C virus...

2006-10-10

2006-10-10

Campbell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S017400, C530S331000, C530S330000, C530S329000

Reexamination Certificate

active

07119073

ABSTRACT:
Compounds of formula (I), and pharmaceutically acceptable salts and esters thereof: (I); wherein Q, R2, X, Y and Z are as defined herein; are inhibitors of the hepatitis C virus (HCV) NS3 protease

REFERENCES:
patent: 4297346 (1981-10-01), Rips et al.
patent: WO 9206108 (1992-04-01), None
patent: WO 98/46630 (1998-10-01), None
patent: WO 99/64442 (1999-12-01), None
Llinas-Brunet, M. et al., “Peptide-Based Inhibitors of the Hepatitis C Virus Serine Protease”, 1998, Bioorganic & Medicinal Chemistry Letters, vol. 8, No. 13, pp. 1713-17318.
Bailey, M.D. et al., “Novel C-Terminal Carboxylic Acid Tri-Peptide Inhibitors of Hepatitis C Virus Serine Protease”, American Chemical Society, vol. 220, pp. MED188 XP00964834 (2000).
Landro, J.A. et al., “Mechanistic Role of an NS4A Peptide Cofactor with the Truncated NS3 Protease of Hepatitis C Virus: Elucidation of the NS4A Stimulatory Effect via Kinetic Analysis and Inhibitor Mapping”, 1997, Biochemistry, vol. 35, No. 11, pp. 9340-9348.
Llinas-Brunet M. et al., “Studies on the C-Terminal of Hexapeptide Inhibitors of the Hepatitis C Virus Serine Protease”, 1998, Biorganic Medicinal Chemistry Letters 8, pp. 2719-2724.
Beilstein Registry No. 8123814, XP-002206365, reference to: Eaton S.R., et al., J. Med. Chem., 1998, vol. 41, No. 22, pp. 4329-4342.
Beilstein Registry No. 5835997, XP002206366, reference to: Rich, D.H., et al., J. Med. Chem., 1992, vol. 35, No. 21, pp. 3803-3812.

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