Peptides and remedy for bone diseases containing the same as...

Details Peptides and remedy for bone diseases containing the same as... Peptides and remedy for bone diseases containing the same as...

2005-08-16

2005-08-16

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S014800

Reexamination Certificate

active

06930091

ABSTRACT:
A new substance useful as a drug for the treatment of osteopathy is disclosed. The present invention provides a peptide and derivative thereof having an amino acid sequence SEQ ID NO: 1 designated hereunder as follows, wherein both of the peptide and derivative thereof having growth promotion effects and activity promotion effects on osteoblasts, as well as a drug having the peptide as an effective component for the treatment of osteopathy:Lys Leu Thr Thr Ile Phe Pro Leu AsnSEQ ID NO: 1 1               5Trp Lys Tyr Arg Lys Ala Leu.10                  15     

REFERENCES:
patent: 5262319 (1993-11-01), Iwata et al.
patent: 6071881 (2000-06-01), Sakamoto
patent: 6420520 (2002-07-01), Sakamoto
Alan H. Gorn et al., “Cloning, Characterization, and Expression of a Human Calcitonin Receptor from an Ovarian Carcinoma Cell Line ” ©The American Society for Clinical Investigation, Inc., Nov. 1992, 1726-1735 (vol. 90) Massachusetts, Journal of Clinical Investigation.
Daniel R. Nussenzveig et al., “Inhibition of Inositol Phosphate Second Messenger Formation by Intracellular Loop One of a Human Calcitonin Receptor”The Journal of Biological Chemistry, Nov. 1994, 28123-28129 (vol. 269) USA.

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