Peptides and processes for producing cyclic peptides

Details Peptides and processes for producing cyclic peptides Peptides and processes for producing cyclic peptides

1993-06-28

1996-04-16

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

530334, 530338, 530339, C07K 102, C07K 104, C07K 14585

Patent

active

055083820

ABSTRACT:
A peptide of the following general formula is subjected to cyclization reaction to produce a cyclic peptide, preferably a synthetic calcitonin derivative (elcatonin) which is a useful medicine. ##STR1## (wherein A and B form a peptide of the formula Ser-Asn-Leu-Ser-Thr (SEQ ID NO: 43); X means a hydroxyl group, a carboxy-protecting group, an amino acid residue or a peptide residue; provided that the side-chain carboxyl group of .alpha.-L-aminosuberic acid is condensed with an amino acid or a peptide). The cyclic peptide can be obtained by subjecting a peptide of the above general formula to (1) cyclization reaction by chemical condensation, (2) cyclization reaction in the presence of an alkali metal salt and (3) reactions using the techniques of liquid phase synthesis and solid phase synthesis in combination.

REFERENCES:
patent: 4043992 (1977-08-01), Fujimoto et al.
patent: 4086221 (1978-04-01), Sakakibara et al.
patent: 4146612 (1979-03-01), Veber
patent: 4161521 (1979-07-01), Veber et al.
patent: 4277393 (1981-07-01), Sakakibara et al.
patent: 4658014 (1987-04-01), Kempe
patent: 4743677 (1988-05-01), Noda et al.
Chemical Abstracts vol. 109:129696e (1988).
Chemical Abstracts vol. 114:99992g (1991).
"Nonreducible Cyclic Analogues of Somatostatin", Journal of the American Chemical Society, 98:8, Apr. 14, 1976 pp. 2367-2369.

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