Peptides and pharmaceutical compositions thereof for treatment o

Details Peptides and pharmaceutical compositions thereof for treatment o Peptides and pharmaceutical compositions thereof for treatment o

1996-04-10

1999-09-07

Duffy, Patricia A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 15, 514 16, 514 17, 514 18, A61K 3800

Patent

active

059487631

ABSTRACT:
Novel peptides capable of interacting with a hydrophobic structural determinant on a protein or peptide for amyloid or amyloid-like deposit formation inhibit and structurally block the abnormal folding of proteins and peptides into amyloid or amyloid-like deposits. Methods for preventing, treating or detecting disorders or diseases associated with amyloid-like fibril deposits, such as Alzheimer's disease and prion-related encephalopathies, are also provided.

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Wood et al, Biochemistry, 34(3):724-730, 1995.
Borman et al, Science Jun. 17, 1996, pp. 33-34.
Rudinger et al "Peptide Hormones" ed Parsons, J.A. University Park Press, Jun. 1976, p. 6.
Burgess et al, The Journal of Cell Biology, 111:2129-2138, 1990.
Lazar et al, Molecular and Cellular Biology, 8(3):1247-1252, 1988.
Chou et al, "Empirical Predictions of Protein Conformation", Ann. Rev. Biochem, 47:251-276 (1978).
Stephen Wood et al, Prolines and Amyloidgenicity in Fragments of the Alzheimers Peptide .beta./A4, Biochemistry, vol. 34, pp. 724-730, 1995.
Claudio Soto et al, Two Conformational States of Amyloid .beta.-Peptide: Implications for the Pathogenesis of Alzheimer's Disease, Neuroscience Letters, vol. 186, pp. 115-118, 1995.
Claudio Soto et al, Structural Determinants of the Alzheimer's Amyloid .beta.-Peptide Journal of Neurochemistry, vol. 63, pp. 1191-1198, 1994.
Claudio Soto et al, The .alpha.-Helical to .beta.-Strand Transition in the Amino-Terminal Fragment of the Amyloid .beta.-Peptide Modulates Amyloid Formation, Journal of Biochemistry, vol. 20, No. 7, pp. 3063-3067, 1995.

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