Peptides and peptidomimetics having anti-proliferative...

Details Peptides and peptidomimetics having anti-proliferative... Peptides and peptidomimetics having anti-proliferative...

2006-02-07

2006-02-07

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C930S020000

Reexamination Certificate

active

06995135

ABSTRACT:
This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells. While the invention is not limited to any particular mechanism, the compounds of the invention appear to function at least in part by inhibiting G2 cell cycle checkpoint. Thus, invention compounds can be used to inhibit cell growth alone or be used in combination with a nucleic acid damaging treatment to inhibit cell growth.

REFERENCES:
patent: 01/21771 (2001-03-01), None
patent: 01/94411 (2001-12-01), None
Suganuma et al., “Sensitization of Cancer Cells to DNA Damage-induced Cell Death by Specific Cell Cycle G2Checkpoint Abrogation”,Cancer Research, Dec. 1, 1999; 59:5887-5891; XP002181645.
Kobayashi et al., “Selective Cancer Cell Killing by a Novel G2 Checkpoint Abrogating Peptide”, Proceedings of the Annual Meeting of the American Assocation for Cancer Research, Mar. 2001; #4892 p. 911, XP-001173131.
Ito et al., “Phylogenetic Relationships of Amaryllidaceae Based on matK Sequence Data”,J. Plant Res., Jun. 1999; 112(1106):207-216, XP008027543.
Hayakawa et al., “Sequence Analysis of theXestia c-nigrumGranulovirus Genome”,Virology, Sep. 30, 1999; 262(2):277-297, XP004439794.
Nestor et al., “Luteinizing Hormone-Releasing Hormone Antagonists Containing Very Hydrophobic Amino Acids”,J. Med. Chem.,1984; 27:1170-1174, XP002288202.
Maryanoff et al., “Protease-Activated Receptor-2 (PAR-2): Structure-Function Study of Receptor Activation by Diverse Peptides Related to Tethered-Ligand Epitopes”,Archives of Biochemistry and Biophysics, Feb. 15, 2001; 386(2):195-204, XP002971306.

Affiliated with

Also associated with

Rating

Peptides and peptidomimetics having anti-proliferative... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides and peptidomimetics having anti-proliferative..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides and peptidomimetics having anti-proliferative... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3677286