Peptides and peptidomimetics binding to CD23

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S021700, C514S021800, C514S021900, C514S021910, C530S328000, C530S329000, C530S330000, C530S331000, C424S185100, C424S193100

Reexamination Certificate

active

08071552

ABSTRACT:
The present invention describes compounds comprising new and useful peptides and peptidomimetics that can bind to CD23. They are capable of reducing inflammatory responses associated with auto-immune diseases, chronic inflammatory diseases, allergies and other inflammatory conditions such as those mediated by the mammalian immune system. Compounds of the present invention relate to a CD23-binding peptide wherein said peptide comprises an amino-acid sequence of X1—X2—X3—X4—X5—X6—X7—X8, wherein: X1is Phe, or is absent; X2is His or Ala; X3is Glu, Ser, Ala, Asn, Lys, or Cys; X4is Asn, Phe, Gln, Pro, Ser, or Ala; X5is Trp; X6is Pro, Arg, Glu, Gly, Cys, or Lys; X7is Ser, Pro, Leu, Thr Ala, Gly, Asn, or absent; and X8is Phe, Gly, or is absent.

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