Peptides and nucleic acids of the cathelicidin family,...

Details Peptides and nucleic acids of the cathelicidin family,... Peptides and nucleic acids of the cathelicidin family,...

2008-04-01

2008-04-01

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C119S231000, C514S012200, C514S013800, C514S015800, C514S021800, C530S324000, C530S326000, C530S328000, C530S857000

Reexamination Certificate

active

07351693

ABSTRACT:
The invention relates to anti-microbial and immunostimulatory molecules of the cathelicidin family derived from fish. The invention provides a novel cathelicidin molecule, fragments, derivatives and uses thereof, and nucleic acids encoding the same.

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Chen, J., et al. “Development of Protegrins for the Treatment of Precention of Oral Mucositis: Structure-Activity Relationship of Synthetic Protegrin Analogues.” Biopolymers (Peptide Science) vol. 55. Jul. 28, 2000. pp. 88-98.
Larrick, J.W., et al. “A Novel Granulocyte-Derived Peptide with Lipopolysaccharide-Neutralizing Activity.” Journal of Immunology, vol. 152. American Association of Immunologists. Oct. 4, 1994. pp. 231-240.
Lillard, JR., J.W., et al. “Mechanisms for induction of acquired host immunity by neutrophil peptide defensins.” Proc. Natl. Acad. Sci., vol. 96. 1999. pp. 651-656.
Gallo, R., et al. “Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds.” Proc. Natl. Acad. Sci., vol. 91. Nov. 1994. pp. 11035-11039.
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