Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-03-12
1995-06-13
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
5303871, C07K 300, C07K 1300, C07K 1500, A61K 3514
Patent
active
054243980
ABSTRACT:
The present invention relates to peptides immunochemically reactive with antibodies to the Epstein-Barr virus (EBV), comprising at least part of the VCA-p18 or VCA-p40 protein, encoded within the EBV open reading frames BFRF3 and BdRF1 respectively, or a functional variant thereof. The invention further relates to nucleic acid sequences encoding these peptides, monoclonal antibodies against these peptides, cell lines capable of producing monoclonal antibodies and anti-idiotype antibodies. The invention also relates to recombinant vector molecules comprising a nucleic acid sequence according to the invention and host cells transformed or transfected with these vector molecules. The invention is further concerned with immunological reagents and methods for the detection of EBV or anti-EBV antibodies and a method for the amplification and detection of Epstein Barr viral nucleic acid.
REFERENCES:
R. Baer et al., "DNA Sequence and Expression of the B95-8 Epstein-Barr Virus Genome," Nature, vol. 310, pp. 207-211, Jul. 19, 1984, London, GB.
G. J. Bayliss and H. Wolf, "The Regulated Expression of Epstein-Barr Virus. III. Proteins Specified by EBV During the Lytic Cycle," J. Gen. Virol. vol. 56, pp. 105-118, London, GB, 1981.
van Grunsven et al. "Gene mapping and expression . . . " J. of Virology 67(7) pp. 3908-3916 Jul. 1993.
Middeldorp Jaap M.
van Grunsven Wouterus M. J.
Akzo N.V.
Blackstone William M.
Gormley Mary E.
Kim Hyosuk
Wax Robert A.
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