Peptides and hair growers having actions of promoting proliferat

Details Peptides and hair growers having actions of promoting proliferat Peptides and hair growers having actions of promoting proliferat

1998-06-30

2000-07-25

Lilling, Herbert J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

424 74, 424880, A01N 6500, A61K 706

Patent

active

060934026

ABSTRACT:
Citrus amanatsudaidai peel extract, which was used as a starting materials was purified over various kinds of column chromatography (activated carbon, Amberlite IR-120B [H.sup.+ ], cellulose, Sephadex G25 and HPLC) to isolate a peptide as a white powder. This peptide is a water-soluble neutral substance and shows positive reactions to ninhydrin and sodium nitroprusside and negative reactions to anisaldehyde, phenolsulfuric acid and Dragendorff reagent. Amino acids constituting the peptide of the present invention contain aspartic acid and oxylysine in large amounts. Hair growers containing the peptide of the present invention were successful in promoting 150% proliferation of rabbit hair papilla cells when applied in a concentration of 1.4 .mu.g/ml.

REFERENCES:
Derwent WPIL Computer Abstract Miyauchi JP09202798, Aug. 5, 1997.
Derwent WPIL Computer Abstract Miyauchi JP09202716, Aug. 5, 1997.

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