Peptides and compounds that bind to the IL-5 receptor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 12, 514 14, 530324, 530325, 530326, 424 854, A61K 3800, C07K 500

Patent

active

056542763

ABSTRACT:
Described are peptides and peptide mimetics that bind to and the IL-receptor. Such peptides and peptide mimetics are useful in methods for treating disorders that involve improper production of or response to IL-5 and or the production and accumulation of eosinophils, such as asthma, as well as in diagnostic methods employing labeled peptides and peptide mimetics.

REFERENCES:
patent: 5096704 (1992-03-01), Coffman et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5270170 (1993-12-01), Schatz et al.
patent: 5338665 (1994-08-01), Schatz et al.
Barker et al., (1992) J. Med. Chem. 35:2040-2048 Cyclic RGD peptide analogues as antiplatelet antihrombotics.
Bodanszky et al., (1966) Chem Ind. (London) 38:1597-1598 Active esters and resins in peptide synthesis.
Caras et al., (1989) Science 243:1196-1198 Signal peptide for protein secretion directing glycophospholipid membrane anchor attachment.
Chiu et al., (1984) Archives Internationales de Pharmacodynamie et de Therapie 270:128-140 Gastric cytoprotective properties of SCH 32651, a novel antiulcer agent.
Cwirla et al., (1990) Proc. Natl. Acad. Sci. USA 87:6378-6382 Peptides on phage: A vast library of peptides for identifying ligands.
Dower et al., (1988) Nucleic Acids Research 16:6127-6145 High efficiency transformation of E. coli by high voltage electroporation.
Dower et al., (1991) Ann. Rep. Med. Chem. 26:271-280 Recombinant and synthetic randomized peptide libraries.
Fodor et al., (1991) Science 251:767-773 Light-directed, spatially addressable parallel chemical synthesis.
Hayashida et al., (1990) Proc. Natl. Acad. Sci. USA 87:9655-9659 Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor GM-CSF receptor.
Lin et al., (1990) Science 249:677-679 Expression of T cell antigen receptor heterodimers in a lipid-linked form.
Lopez et al., (1988) J. Exp. Med. 167:219-224 Recombinant human Interleukin 5 is a selective activator of human eosinophil function.
Murata (1992) J. Exp. Med. 175:341-351 Molecular cloning and expression of the human interleukin 5 receptor.
Or et al., (1991) J. Org. Chem. 56: 3146-3149 Cysteine alkylation in unprotected peptides: synthesis of a carbavasopressin analogue by intramolecular cysteine alkylation.
Plaetinick et al., (1990) J. Exp. Med. 172:683-691 Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells.
Raeburn et al., (1992) J. Pharmacol. Toxicol. Meth. 27:143-159 Techniques for drug delivery to the airways and the assessment of lung function in animal models.
Rizo et al., (1992) Annu. Rev. Biochem. 61:387-418 Constrained peptides: Models of bioactive peptides and protein substructures.
Rolink et al., (1989) J. Exp. Med. 169:1693-1701 Monoclonal antibodies reactive with the mouse Interleukin 5 receptor.
Saito et al., (1988) Proc. Natl. Acad. Sci. USA 85:2288-2292 Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins.
Wanner et al., (1990) Am. Rev. Respir Dis. 141:253-257 Models of airway hyperresponsiveness.
Yamaguchi et al., (1988) J. Exp. Med 167:43-56 Purified Interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Peptides and compounds that bind to the IL-5 receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides and compounds that bind to the IL-5 receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides and compounds that bind to the IL-5 receptor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1074835

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.