Peptides and compounds that bind to the IL-1 receptor

Details Peptides and compounds that bind to the IL-1 receptor Peptides and compounds that bind to the IL-1 receptor

1994-02-02

1997-03-04

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530328, A61K 3800, A61K 3802, C07K 500, C07K 700

Patent

active

056080352

ABSTRACT:
Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W (SEQ ID NO: 1) where Z.sub.1 is L, I, A, or Q; (2) XXQZ.sub.5 YZ.sub.6 XX (SEQ ID NO: 6) where Z.sub.5 is P or Aze where Aze is azetidine; and Z.sub.6 is S, A, V, or L; and (3) Z.sub.23 NZ.sub.24 SZ.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub.29 Z.sub.30 L (SEQ ID NO: 17) where Z.sub.23 is D or Y; Z.sub.24 is D or S; Z.sub.25 is S or W; Z.sub.26 is S or Y; Z.sub.27 is D or V; Z.sub.28 is S or W; Z.sub.29 is F or L; and Z.sub.30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids.

REFERENCES:
patent: 4968607 (1990-11-01), Dower et al.
patent: 5039790 (1991-08-01), Adams et al.
patent: 5075222 (1991-12-01), Hannum et al.
patent: 5075288 (1991-12-01), Krueger et al.
patent: 5077219 (1991-12-01), Auron et al.
Dower et al., 1990, J. Clin. Immunol. 10(6):289-299 Human cytokine receptors.
Cwirla et al., Aug. 1990, Proc. Natl. Acad. Sci. USA 87:6378-6382 Peptides on phage: A vast library of peptides for identifying ligands.
Larrick, 1989, Immunol. Today 10(2):61-66 Native interleukin-1 inhibitors.
Bender and Lee, 1989, Ann. Rep. Med. Chem. 25:185-193 Chapter 20: Pharmacological modulation of interleukin-1.
Dower and Urdal, 1987, Immunol. Today 8(2):4-51 the interleukin-1 receptor.
Labriola-Tompkins et al., Dec. 1991, Proc. Natl. Acad. Sci. USA 88:11182-11186 Identification of the discontinuous binding site in human interleukin 1beta for the tpe I interlekin 1 receptor.
McMahan et al., 1991, EMBO J. 10(10):2821-2832 A novel IL-1 receptor, cloned from B cells by mammalian expression, in expressed in many cell types.
Fodor et al., 15 Feb. 1991, Science 251:767-773 Light-directed, spatially addressable parallel chemical synthesis.
Dinarello, 1991, Blood 77(8):1627-1652 Interleukin-1 and interleukin-1 antagonism.
Hannum et al., 1991, Nature 343:336-340 Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor.

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