Peptides and compounds that bind to ELAM-1

Details Peptides and compounds that bind to ELAM-1 Peptides and compounds that bind to ELAM-1

1995-02-16

1997-07-15

Tsang, Cecilia

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530327, A61K 3800, C07K 708, C07K 1400

Patent

active

056484585

ABSTRACT:
The peptide HITWDQLWNVMN (SEQ ID NO: 4) and related peptides and peptidomimetics bind to endothelial leukocyte adhesion molecule 1 and block the binding of leukocytes to this important receptor and so can be used to ameliorate the detrimental effects of certain disease conditions.

REFERENCES:
patent: 4680265 (1987-07-01), Birmingham et al.
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5053392 (1991-10-01), Klein et al.
patent: 5075222 (1991-12-01), Hannum et al.
patent: 5081034 (1992-01-01), Bevilacqua et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5166133 (1992-11-01), Houston et al.
patent: 5208253 (1993-05-01), Boschelli
patent: 5258289 (1993-11-01), Davis et al.
patent: 5268364 (1993-12-01), Kojima et al.
patent: 5324591 (1994-06-01), Georger, Jr. et al.
Roemer et al, PNAS, vol. 88, pp. 11295-11299. 1991.
Edgington, Biotechnology, vol. 10, pp. 383-389, 1992.
Barrett, et al, Analytical Biochemistry, 204, 357-364 pp. (1992).
Cwirla, et al, Proc. Natl. Acad. Sci, 87, 6378-6382 (1990).
Bochelli, J., "3-Alkoxybenzo[b]thiophene-2-carboxamides as Inhibitors of Neutrophil-endothelial Cell Adhesion", Medical Chem., 37(6).
Cho, Charles, Y. et al., "An Unnatural Biopolymer", Science, vol. 261, Sep. 3, 1993, pp. 1303-1305.
Geng, Jian-Guo et al., "Rapid Neutrophil Adhesion to Activated Endothelium Mediated by GMP-140", Nature, vol. 343, Feb. 22, 1990, pp. 757-760.
Hession C. et al., "Endothelial Leukocyte Adhesion Molecule 1: Direct Expression Cloning and Functional Interactions", Proc. Nat. Acad. Sci. USA, vol. 87 (Cell Biology), Mar. 1990, pp. 1673-1677.
Johnston, Geoffrey I. et al., "Cloning of GMP-140, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Inflammation", Cell, pp. 1034-1044. (1990).
Oliphant, Arnold R. et al., "Defining the Sequence Specificity of DNA-Binding Proteins by Selecting Binding Sites from Random-Sequence Oligonucleotides: Analysis of Yeast GCN4 Protein", Molecular and Cellular Biology, vol. 9, No. 7, Jul. 1989, pp. 2944-2949.
Spertini, Olivier et al., "Regulation of Leukocyte Migration by Activation of the Leukocyte Adhesion Molecule-1 (LAM-1 Selectin)", Nature, vol. 349, Feb. 21, 1991, pp. 691-693.
Springer, Timothy A., "Adhesion Receptors of the Immune System", Review Article, Nature, vol. 346, Aug. 2, 1990, pp. 425-434.
Bender et al, "Chapter 20: Pharmacological Modulation of Interleukin-1," Ann. Rep. Med. Chem., vol. 25:185-193.
Bevilacqua et al, "Selectins: A Family of Adhesion Receptors," Cell, Oct. 18, 1991, vol. 67:233.
Ezzell, "Sticky Situations: Picking Apart the Molecules that Glue Cells Together," Science News, Jun. 13, 1992, vol. 141:392-395.
Goelz et al, "ELFT: A Gene that Directs the Expression of an ELAM-1 Ligand," Cell, 1990, vol. 63:1349-1356.
Parekh, "Oligosaccharides as Specific Ligands for the LECAMs," Tech. Bull. 11, 1991, Oxford GlycoSystems Ltd.
Phillips et al, "ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Lex," Science, Nov. 23, 1990, vol. 25:1130-1135.
Polley et al, "CD62 and Endothelial Cell-Leukocyte Adhesion Molecule 1 (ELAM-1) Recognize the Same Carbohydrate Ligand, Sialyl-Lewis x," PNAS, USA, Jul. 1991, vol. 88:6224-6228.
Rice et al, "An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion," Science, Dec. 8, 1989, vol. 246:1303-1306.
Tiemeyer et al, "Carbohydrate Ligands for Endothelial-Leukocyte Adhesion Molecule 1," PNAS, USA, Feb. 1991, vol. 88:1138-1143.
Tyrrell et al, "Structural Requirements for the Carbohydrate Ligand of E-Selectin," PNAS USA, Nov. 1991, vol. 88:10372-10376.
Paulson, Selectin/carbohydrate-mediated adhesion of leukocytes, Adhesion: It's Role in Inflammatory Disease, Chapter 2, pp. 19-42 (1992).
Picker et al., ELAM-1 is an adhesion molecule for skin-homing T cells (1991) Nature 349:796-799.
Schimizu et al., Activation-independent binding of human memory T cells to adhesion molecule ELAM-1 (1991) Nature 349:799-802.
Collins et al., Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1 (1991) J. Biol. Chem. 266:2466-2473.

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