Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides
Reexamination Certificate
2006-08-15
2006-08-15
Gupta, Anish (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Cyclic peptides
C530S326000, C530S327000, C530S328000, C424S001690
Reexamination Certificate
active
07091311
ABSTRACT:
Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
REFERENCES:
patent: 5141851 (1992-08-01), Brown et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5270170 (1993-12-01), Schatz et al.
patent: 5326558 (1994-07-01), Turner et al.
patent: 5338665 (1994-08-01), Schatz et al.
patent: 5358934 (1994-10-01), Borovsky et al.
patent: 5384331 (1995-01-01), Kogan et al.
patent: 5411942 (1995-05-01), Widmer et al.
patent: 5869451 (1999-02-01), Dower et al.
patent: 5932546 (1999-08-01), Barrett et al.
patent: 6083913 (2000-07-01), Dower et al.
patent: 0 690 127 (1995-01-01), None
patent: 0 668 352 (1995-02-01), None
patent: 0 675 201 (1995-03-01), None
patent: 2186579 (1987-08-01), None
patent: 2 285 446 (1995-07-01), None
patent: WO 90/15070 (1990-12-01), None
patent: WO 91/07988 (1991-06-01), None
patent: WO 91/08752 (1991-06-01), None
patent: WO 93/25221 (1993-12-01), None
patent: WO 95/11922 (1995-05-01), None
patent: WO 95/18858 (1995-07-01), None
patent: WO 95/21626 (1995-08-01), None
patent: WO 95/21919 (1995-08-01), None
patent: WO 95/21920 (1995-08-01), None
patent: WO 95/28907 (1995-11-01), None
patent: WO 96/17062 (1996-06-01), None
patent: WO 96/17062 (1996-06-01), None
patent: WO 96/17067 (1996-06-01), None
Barker et al., “Cyclic RGE peptide analogues as antiplatelet antithrombotics”. J. Med. Chem., vol. 35:2040-2048 (1992).
Bartley et al., “Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI”. Cell. vol. 77:1117-1124 (1994).
Bazan, “Structural design and molecular evolution of a cytokine receptor superfamily”. Proc. Natl. Acad. Sci. USA. vol. 87:6934-6938 (1990).
Caras et al., “Signal peptide for protein secretion directing glycophospholipid membrane anchor attachment”, Science, vol. 243:1196-1198 (1989).
Cwirla et al., “Peptides on phage: A vast library of peptides for identifying ligands”. Proc. Natl. Acad. Sci. USA, vol. 87:6378-6382 (1990).
Dexter et al., “Growth factor-dependent hemopoietic precursor cell lines”, J. Exp. Med., vol. 152:1036-1047 (198).
Dower et al., The search for molecular diversity (II): Recombinant and synthetic randomized peptide libraries:, Ann. Rep. Med. Chem., vol. 26:271-280 (1991).
Dower et al., “High efficiency transformation of E. coli by high voltage electroporation”, Nucleic Acids Research, vol. 16:6127 (1988).
Fodor et al., “Light-directed, spatially addressable parallel chemical synthesis”, Science, vol. 251:767-773 (1991).
Harker, “Kinetics of thrombopoiesis”, J. Clin. Invest., vol. 47:458-465 (1968).
Kaushansky et al., “Promotion of megakaryocyte progenitor expansion and differentiation by the e-Mp1 ligand thrombopoietin”, Nature, vol. 369:568-571 (1994).
Kojima et al., Molecular cloning and expression of megakaryocyte potentiating factor cDNA, J. Biol. Chem., vol. 270:21984-21990 (1995).
Kuter et al., “The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production”, Proc. Natl. Acad. Sci. USA, vol. 91:11104-11108 (1994).
McDonald, “Thrombopoietin—Its biology, clinical aspects and possibilities”, Am. J. Pediatric Hematology/Oncology, vol. 14:8-21 (1992).
Metcalf, “Thrombopoietin—at last”, Nature, vol. 369:519-520 (1994).
Methia et al., “Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis”, Blood, vol. 82:1395-1401 (1993).
Mossmann, “Rapid colorimetirc assays for cellular growth and survival: Application to proliferation and cytotoxicity assays”, J. Immunol. Methods, vol. 65:55-63 (1983).
Or et al., Cysteine alkylation in unprotected peptides: Synthesis of a carbavasopressin analogue by intramolecular cysteine alkylation, J. Org. Chem., vol. 56:3146-3149 (1991).
de Sauvage et al., “Stimulation of megakaryoctyopoiesis and thrombopoiesis by the c-Mp1 ligand”. Nature, vol. 369:533-538 (1994).
Souyri et al., A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors, Cell. vol. 63:1137-1147 (1990).
Vigon et al., “Molecular cloning and characterization of MPI., the human homolog of the v-mpi oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily”, Proc. Natl. Acad. Sci. USA. vol. 89:5640-5644 (1992).
Verber et al., “The design of metabolically-stable peptide analogs”, Trends in Neurosciences (TINS), pp. 392-396 (1990).
Wendling et al., “The oncongene V-MPI., A putative truncated cytokine receptor which immortalizes hematopoietic progenitors”. I. Inserm. pp. 145-146 (1992).
Wendling et al., e-MpI ligand is a humoral regulator of megakaryocytopoisis. Nature:571-574 (1994).
Kato et al., “Purification and Characterization of Thrombopoietin”. J. Biochem. vol. 118:229-236 (1995).
Wada et al., “Characterization of the Truncated Thrombopoietin Variants”. Biophysical Research Communications. vol. 213:1091-1098 (1995).
Barrett Ronald W.
Cwirla Steven E.
Dower William J.
Duffin David J.
Gates Christian M.
Gupta Anish
SmithKline Beecham Corporation
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