Peptides and compounds that bind selectins including endothelium

Details Peptides and compounds that bind selectins including endothelium Peptides and compounds that bind selectins including endothelium

1995-05-12

1998-03-17

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530327, 530328, 530329, 530330, 530331, 514 12, 514 15, 514 17, 514 18, A61K 3800, C07K 700, C07K 500

Patent

active

057288020

ABSTRACT:
Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.

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