Peptides and compounds that bind selectins including endothelium

Details Peptides and compounds that bind selectins including endothelium Peptides and compounds that bind selectins including endothelium

1995-06-07

1998-07-28

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 13, 514 14, 514 15, 514136, 514143, 530324, 530327, 530326, 530328, 530317, 530332, A61K 3800, C07K 500, C07K 700, C07K 1600

Patent

active

057863229

ABSTRACT:
Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.

REFERENCES:
patent: 4680265 (1987-07-01), Birmingham et al.
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5053392 (1991-10-01), Klein et al.
patent: 5075222 (1991-12-01), Hannum et al.
patent: 5081034 (1992-01-01), Bevilacqua et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5166133 (1992-11-01), Houston et al.
patent: 5198424 (1993-03-01), McEver
patent: 5208253 (1993-05-01), Boschelli et al.
patent: 5258289 (1993-11-01), Davis et al.
patent: 5268364 (1993-12-01), Kojima et al.
patent: 5324591 (1994-06-01), George, Jr. et al.
patent: 5440015 (1995-08-01), Macher et al.
Barrett et al., 1992, Analytical Biochemistry 204: 357-364 Selective enrichment and characterization of high affinity ligands collections of random peptides on filamentous phage.
Bender and Lee, 1989, Ann. Rep. Med. Chem. 25: 185-193 Chapter 20: Pharmacological Modulation of Interleukin-1.
Bevilacqua et al., 18 Oct. 1991, Cell 67: p. 233 Selectins: A family of adhesion receptors.
Boschelli et al., 1994, J. of Medicinal Chem., 37(6): 717-718 neutrophil-endothelial cell adhesion.
Cho et al., 3 Sep. 1993, Science 261: 1303-1305 An Unnatural Biopolymer.
Collins et al., 1991, J. Biol. Chem. 266(4): 2466-2473 Structure and Chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1.
Cwirla et al., 1990, P.N.A.S. USA, 87: 6378-6382 Peptides on phage: A vast library of peptides for identifying ligands,
Edington, Apr. 1992, Biotechnology 10: 383-389 How Sweet It Is: Selectin-Mediating Drugs.
Ezzell, 13 Jun. 1992, Science News 141:392-395 Sticky Situations: Picking apart the molecules that glue cells together.
Geng et al., 1990, Nature 343: 757-760 Rapid neutrophil adhesion to activated endothelium mediated by GMP-40.
Goelz et al., 1990, Cell 63: 1349-1356 ELFT: A gene that directs the expression of an ELAM-1 ligand.
Hession et al., 1990, Proc. Natl. Acad. Sci. USA 87: 1673-77 Endothelial leukocyte adhesion molecule 1: Direct expression cloning and functional interactions.
Johnston et al., 24 Mar. 1989, Cell 56: 1033-1044 Cloning of GMP-40, a Granule Membrane Protein of Platelets and Endothelium: Sequence Similarity to Proteins Involved in Cell Adhesion and Immflamation.
Oliphant et al., Jul. 1989, Amer. Soc. Microbiol. 9(7): 2944-2949 Defining the sequence specificity of DNA-binding proteins by selecting binding sites from Random-sequence oligonucleotides: analysis of yeast GCN4 protein.
Parekh, 1991, Oxford GlycoSystems Ltd., Tech. Bull. 11 Oligosaccharides as specific ligands for the LECAMs.
Paulson, Adhesion: It's Role in Inflammatory Disease, Chapter 2, pp. 19-42 Selectin/Carbohydrate-Mediated Adhesion of Leukocytes.
Picker et al., 28 Feb. 1991, Nature 349: 796-799 ELAM-1 is an adhesion molecule for skin-homing T cells.
Polley et al., Jul. 1991, Proc Natl. Acad. Sci. USA 88: 6224-6228 CD62 and endothelial cell-leukocryte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x.
Rice, et al., 1989, Science 246: 1303-1306 An Inducible Endothelial Cell Surface Glycoprotein mediates Melanoma Adhesion.
Shimizu et al., 28 Feb. 1991, Nature 349: 799-802 Activation-independent binding of human memory T cells to adhsion molecule ELAM-1.
Spertini et al., 21 Feb. 1991, Nature 349: 691-694 Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin.
Springer, 2 Aug. 1990, Nature 346:425-434 Adhesion receptors of the immune system.
Tiemeyer et al., Feb. 1991, Proc. Natl. Acad. Sci. USA 88: 1138-1142 Carbohydrate ligands for endothelial-leukocyte adhesion molecule 1.
Tyrrell et al., Nov. 1991, Proc. Natl. Acad. Sci. USA 88: 10372-10376 Structural requirements for the carbohydrate ligand of E-selectin.
Phillips et al., 23 Nov. 1990, Science 25: 1130-1135 ELAM-1 Mediates Cell Adhesion by recognition of a Carbohydrate Ligand, Sialyl-Lex.
Edington Apr. 1992. Science News 141:392-395.

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