Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-05-12
1997-08-12
Fleisher, Mindy
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530325, 530326, 530327, 530328, 530329, 530330, C07K 706, C07K 708, C07K 1447
Patent
active
056567251
ABSTRACT:
The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the "GD domain," which is essential both to Bak's interaction with Bcl-x.sub.L, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.
REFERENCES:
patent: 5015568 (1991-05-01), Tsujimoto
patent: 5202429 (1993-04-01), Tsujimoto
patent: 5283173 (1994-02-01), Fields et al.
Chittenden, et al., Nature 374:733-736 (20 Apr. 1995).
Chittenden, et al., EMBO J. 14(22):5589-5596 (1995).
Haigh, et al., Nature 344: 257-259 (1990).
Bitterman, et al., Repair After Acute Lung Injury, Chest 105(3):P 118S-121S (1994).
Boise, et al, Bcl-x, A Bcl-2-Related Gene That Functions As A Dominant Regulator of Apoptotic Cell Death, Cell 74:597-608 (1993).
Henderson, et al., Epstein-Barr Virus-Coded BHRF1 Protein, A Viral Homologue of BCl-2, Protects Human B Cells From Programmed Cell Death, Proc. Natl. Acad. Sci. USA 90:8479-8483 (1993).
Hengartner, et al., Caenorhabditis Elegans Gene Ced-9 Protects Cells From Programmed Cell Death, Nature 356:494-499 (1992).
Hibner, et al., Signaling Of Programmed Cell Death Induction In WEHI-231 B Lymphoma Cells, Eur. J. Immunol. 23(11):2821-2825 (1993).
Hockenbery, et al, BCL2 Protein Is Topographically Restricted In Tissues Characterized By Apoptotic Cell Death, Proc. Natl. Acad. Sci. USA 88:6961-6965 (1991).
Korsmeyer, et al. BCl-2/Bax: A Rheostat That Regulates An Anti-Oxidant Pathway And Cell Death, Cancer Biology 4:327-332 (1993).
Kozopas, et al., MCL1, A Gene Expressed In Programmed Myeloid Cell Differentiation, Has Sequence Similarity To BCL2, Proc. Natl. Acad. Sci. USA 90:3516-3520 (1993).
Oltvai, et al., Bcl-2-Heterodimerizes In Vivo With A Conserved Homolog, Bax, That Accelerates Programed Cell Death, Cell 74:609-619 (1993).
Carson, et al., Apoptosis And Disease, The Lancet, 341:1251-1254 (1993).
Reed, et al., Antisense-Mediated Inhibition of BCL2 Protooncogene Expression And Leukemic Cell Growth Survival: Comparisons of Phosphodiester And Phosphorothioate Oligodeoxynucleotides, Cancer Research 50:6565-6570 (1990).
Yin, et al., BH1 And BH2 Domains Of Bcl-2 Are Required For Inhibition Of Apoptosis And Heterodimerization With Bax, Nature 369:321-323 (1994).
Williams, Programmed Cell Death: Apoptosis And Oncogenesis, Cell 65:1097-1098 (1991).
Lin, et al., Characterization Of A1, A Novel Hempoietic-Specific Early-Response Gene With Sequence Similarity To Bcl-2, The Journal of Immunology 151:1979-1988 (1993).
Neilan, et al., An African Swine Fever Virus Gene With Similarity To The Proto-Oncogene Bcl-2 And The Epstein-Barr Virus Gene BHRF1, Journal of Virology 67:4391-4394 (1993).
Campos, et al., Effects Of BCl-2 Antisenses Oligodeoxynucleotides On In Vitro Proliferation And Survival Of Normal Marrow Progenitors And Leukemic Cells, Blood 84:595-600 (1994).
Williams, et al., Molecular Regulation Of Apoptosis: Genetic Controls On Cell Death, Cell 74:777-779 (1993).
Fanidi, et al., Coperative Interaction Between C-myc And Bcl-2 Proto-Oncogenes, Nature 359:554-556 (1992).
Hengartner, et al., C. Elegans Cell Survival Gene Ced-9 Encodes A Functional Homolog Of The Mammalian Proto-Oncogene Bcl-2, Cell 76:665-676 (1994).
Vaux, et al., Prevention Of Programmed Cell Death In Caenorhabditis Elegans By Human Bcl-2, Science 258:1955-1957 (1992).
Hockenbery, et al., Bcl-2 Is An Inner Mitochondrial Membrane Protein That Blocks Programmed Cell Death, Nature 348:334-336 (1990).
Evan, et al., Induction Of Apoptosis In Fibroblasts By C-myc Protein, Cell 69:119-128 (1992).
Harrington, et al., C-Myc-Induced Apoptosis In Fibroblasts Is Inhibited by Specific Cytokines, The EMBO Journal 13:3286-3295 (1994).
Casey, Protein Lipidation in Cell Signaling, Science:268-221-225 (1995).
Guarente, Strategies for the identification of interacting proteins Proc. Natl. Acad. Sci: 90:1639-1641 (1993).
Germino, et al., Screening for in vivo protein-protein interactions Proc. Natl. Acad. Sci.: 90:933-937 (1993).
Reed, Bcl-2 And The Regulation Of Programmed Cell Death, J. Cell. Biol. 124:1-6 (1994).
Tanaka, et al., Cellular Commitment To Oncogene-Induced Transformation Or Apoptosis Is Dependent On The Transcription Factor IRF-1, Cell 77:829-839 (1994).
Rao, et al., The Adenovirus E1A Proteins Induce Apoptosis, Which Is Inhibited By The E1B 19-kDa And Bcl-2 Proteins, Proc. Natl. Acad. Sci. USA 89:7742-7746 (1992).
Wu, et al., P53 And E2F-1 Cooperate To Mediate Apoptosis, Proc. Natl. Acad. Sci. USA 91:3602-3606 (1994).
Chittenden Thomas D.
Lutz Robert J.
Apoptosis Technology, Inc.
Fleisher Mindy
McKelvey Terry A
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