Peptides and compositions

Details Peptides and compositions Peptides and compositions

1986-11-14

1989-03-28

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530325, 530326, 530327, 530328, 530329, 530330, A61K 3702, C07K 710, C07K 708, C07K 706

Patent

active

048164410

ABSTRACT:
Peptides of the formula R.sup.1 -His-Asp-Glu-Ala-R wherein R.sup.1 is Ala-Gln, and R is a polypeptide residue with up to 50 amino acid residues, and wherein one, more or all of the amino acid residues in R.sup.1 and/or R independently may be omitted, can be used to augment cell mediated cytotoxicity and thereby to treat cancers and viral infections. These peptides may be prepared by proteolytic digestion of Staphylococcus aureus protein A, as well as by protein synthesis, recombinant DNA methods or any other methods known in the art.

REFERENCES:
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Guss et al., Eur. J. Biochem. 153: 579-585 (1985).
Ghetie et al., Mol. Immunol. 23(4): 377-384 (1986).
Laky et al., Mol. Immunol. 22(11): 1297-1302 (1985).
Moks et al., Eur. J. Biochem. 156: 637-643 (1986).
Ainsworth et al., Cancer 61: 1495-1500 (1988).

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