Peptides and antibodies to MUC 1 proteins

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C424S130100, C424S133100, C424S134100, C424S138100, C435S007200, C435S007230

Reexamination Certificate

active

07897351

ABSTRACT:
The invention relates to methods of inhibiting proliferation or growth of tumor cells and/or inducing cell death in cancer cells. This invention relates to the use of antibodies, hybridomas and pharmaceutical compositions containing same, for inhibiting growth or proliferation and inducing death in epithelial, colon, lung, breast and ovarian tumor cells or other cells which express MUC1 proteins.

REFERENCES:
patent: 5530101 (1996-06-01), Queen et al.
patent: WO 96/03502 (1996-02-01), None
patent: WO 99/40881 (1999-08-01), None
patent: WO 02/22685 (2002-03-01), None
Rosenblum, Shawver, Marks, Brink, Cheung, and Langton-Webster. Recombinant immunotoxins directed against the c-erb-2/HER2
eu oncogene product: in vitro cytotoxicity, pharmacokinetics, and in vivi efficacy studies in xenograft models. Clinical Cancer Research, 1999. vol. 5, pp. 865-874.
Hartman et al.,International Journal of Cancer, 82:256-267 (Jun. 3, 1999).
Zrihan-Licht et al.,European Journal of Biochemistry, 224 :787-795 (1994).
Price et al.,Tumor Biology, 19(Suppl. I):1-20 (1998).
Hilkens and Boer,Tumor Biology, 19(Suppl. I):67-70 (1998).

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