Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1988-03-31
1992-05-19
Weimar, Elilzabeth C.
Drug, bio-affecting and body treating compositions
Lymphokine
43524027, 435 72, 435 724, 435 721, 530326, 530300, 5303879, 53038822, 5303887, 424 9, 935107, 935110, C12Q 100, A61K 3700, A61K 4900, C07K 700
Patent
active
051148420
ABSTRACT:
A polypeptide analog capable of immunologically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that immunoreacts with the polypeptide and hGPIIb when hGPIIb is present as a platelet-associated GPPIb-IIIa/fibrinogen complex is also disclosed. Further disclosed are diagnostic systems and methods for assaying fibrinogen-bound platelets in a vascular fluid sample using the polypeptides and/or antibodies of the invention.
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Ginsberg Mark H.
Plow Edward F.
Bingham Douglas A.
Chambers Jasemine C.
The Scripps Research Institute
Weimar Elilzabeth C.
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