Peptides and antibodies that inhibit platelet adhesion

Drug – bio-affecting and body treating compositions – Lymphokine

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43524027, 435 72, 435 724, 435 721, 530326, 530300, 5303879, 53038822, 5303887, 424 9, 935107, 935110, C12Q 100, A61K 3700, A61K 4900, C07K 700

Patent

active

051148420

ABSTRACT:
A polypeptide analog capable of immunologically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that immunoreacts with the polypeptide and hGPIIb when hGPIIb is present as a platelet-associated GPPIb-IIIa/fibrinogen complex is also disclosed. Further disclosed are diagnostic systems and methods for assaying fibrinogen-bound platelets in a vascular fluid sample using the polypeptides and/or antibodies of the invention.

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