Peptides and antibodies that inhibit platelet adhesion

Details Peptides and antibodies that inhibit platelet adhesion Peptides and antibodies that inhibit platelet adhesion

1992-05-15

1996-03-12

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 725, 435 729, 424 91, 4241301, 4241391, 4241431, 4241851, 424 149, 424 153, A61K 4900, A61K 3900, G01N 3353

Patent

active

054984998

ABSTRACT:
A polypeptide analog capable of immunologically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that immunoreacts with the polypeptide and hGPIIb when hGPIIb is present as a platelet-associated GPIIb-IIIa/fibrinogen complex is also disclosed. Further disclosed are diagnostic systems and methods for assaying fibrinogen-bound platelets in a vascular fluid sample using the polypeptides and/or antibodies of the invention.

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