Peptides and antibodies that inhibit integrin-ligand binding

Details Peptides and antibodies that inhibit integrin-ligand binding Peptides and antibodies that inhibit integrin-ligand binding

1989-10-02

1993-04-20

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530324, 530327, 530381, 5303879, 530395, 53038822, 5303887, 5303896, 536 235, 514 12, 514 13, 514 14, 514 15, 424 858, 435 696, C07K 1300, C07K 1500, C07K 1528, C07H 2104

Patent

active

052044459

ABSTRACT:
Polypeptides which are derived from the Arg-Gly-Asp (RGD) binding portion of an Integrin beta subunit are disclosed as are their use for modulation of Integrin ligand binding. Anti-peptide antibodies, hybridomas secreting these antibodies, as well as methods of making and using such antibodies, and recombinant DNA molecules that define the structural gene coding for the polypeptides are also contemplated as within the scope of the present invention.

REFERENCES:
Calvete et al., Abstract, (1991) Biochem. J. 274, 457-464.
Calvete et al (1988) Biochem. J. 250, 697-704.
Fitzgerald et al. (1987) J. Biol. Chem. 262, 3936-3939.
Vaitukaitis (1981) Meth. Enzymol. 73, 46-52.

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