Peptides and antibodies that inhibit integrin-ligand binding

Details Peptides and antibodies that inhibit integrin-ligand binding Peptides and antibodies that inhibit integrin-ligand binding

1989-12-01

1993-03-23

Lacey, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530325, 530326, 530327, 530387, 536 27, C07K 706, C07K 708, C07K 710, C07K 1528

Patent

active

051965119

ABSTRACT:
Polypeptides which are derived from the ligand-binding portion of an Integrin alpha subunit are disclosed as are their use for modulation of Integrin ligand binding. Anti-peptide antibodies, hybridomas secreting these antibodies, as well as methods of making and using such antibodies, and recombinant DNA molecules that define the structural gene coding for the polypeptides are also contemplated as within the scope of the present invention.

REFERENCES:
Shadle et al. "Platelet-Collagen Adhesion: Inhibition by a Monoclonal Antibody That Binds Glycoprotein IIb" J. Cell Biology, vol. 99, pp. 2056-2060, Dec. 1984.
Poncz "Structure of the Platelet Membrane Glycoprotein IIb", J. Biolog. Chem. vol. 262(18), pp. 8476-8482, Jun. 1987.
Mehra et al. "Efficient Mapping of Protein Antigenic Determinants" Proc. Natl. Acad. Sciences USA, vol. 83 pp. 7013-7017, Sep. 1986.
Ausubel et al., Current Protocols in Molecular Biology, vol. 2, Suppl. 12, pp. A.1.10-A.1.11 (1991).
Frelinger et al., The Jour. of Biol. Chem., 263:12397-12402 (1988).
Pytela et al., Science, 231:1559-1562, 1986.
Plow et al., Proc. Natl. Sci. USA, 83:6002-6006, 1986.
Charo et al., Proc. Natl. Acad. Sci. USA, 83:8351-8355, 1986.
Santoro et al., Cell, 48:867-873, 1987.
Ginsberg et al., J. Biol. Chem, 262:5437-5440, 1987.
Suzuki et al., J. Biol. Chem., 262:14080-14085, 1987.
Argraves et al., J. Cell Biol., 105:1183-1190, 1987.
Phillips, et al., Blood, 71:831-843, 1988.
Corbi et al., J. Biol. Chem., 263:12403-12411, 1988.
Takada et al., J. Cell Biol., 109:397-407, 1989.
Takada et al., EMBO J. *:1361-1368, 1989.
Larson et al., J. Cell Biol. 108:703-712, 1989.

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