Peptides and antibodies that inhibit integrin-ligand binding

Details Peptides and antibodies that inhibit integrin-ligand binding Peptides and antibodies that inhibit integrin-ligand binding

1988-10-03

1992-09-22

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

5303879, 530830, 53038822, 5303887, 5303882, 536 27, 435 691, 435 696, 4351723, 4352201, C07K 700, C07K 1528, C12N 1511, C12N 1500

Patent

active

051497808

ABSTRACT:
Polypeptides which are derived from the Arg-Gly-Asp (RGD) binding portion of an Integrin beta subunit are disclosed as are their use for modulation of Integrin ligand binding. Anti-antibody peptides, hybridomas secreting these antibodies, as well as methods of making any using such antibodies, and recombinant DNA molecules that define the structural gene coding for the polypeptides are also contemplated within the scope of the present invention.

REFERENCES:
Calvete et al., Abstract, (1991), Biochem. J. 274, 457-464.
Alberts et al., "Molecular Biology of the Cell", Garland Publishing, Inc., New York (1983).
Calvete et al. (1988), Tryptic Digestion of Human GPIIIa. Biochem. J. 250, 697-704.
Fitzgerald et al. (1987) Protein Sequence of Endothelial Glycoprotein IIIa Derived from a cDNA clone. J. Biol. Chem. 262, 3936-3939.

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