Peptides and antibodies that inhibit integrin-ligand binding

Details Peptides and antibodies that inhibit integrin-ligand binding Peptides and antibodies that inhibit integrin-ligand binding

1990-11-29

1993-11-16

Ossanna, Nina

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530324, 530325, 530327, 530328, 5303882, 5303891, 536 235, C07K 0708, C07K 0710

Patent

active

052625206

ABSTRACT:
Polypeptides derived from the ligand-binding portion of an Integrin alpha subunit are disclosed as are their use for modulation of Integrin ligand binding. Anti-peptide antibodies, hybridomas secreting the antibodies, as well as methods of making and using such antibodies and recombinant DNA molecules coding for the polypeptides are also described. The polypeptides and antibodies to the polypeptides are effective inhibitors of fibrinogen binding to platelets.

REFERENCES:
Dane et al. "Two Functional Domains in the Phagocyte Membrane . . . " J. of Immunology v. 137, pp. 3259-3263, Nov. 15, 1986.
Hildreth et al. "The Human Lymphocyte Function-Associated . . . " Journal of Immunology v. 134, pp. 3272-3280, May 1985.
Corbi et al. "the Human Leukocyte Adhesion Colycoprotein MAC-1 . . . " J. Biol. Chemistry, v. 263 (25), pp. 12403-12411, Sep. 5, 1988.
Mehra et al. "Efficient Mapping of Protein Antigenic Determinants" Proc. Natl. Acad. Sci. U.S.A. vol. 83, pp. 7013-7017, Sep. 1986.

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