Peptides affecting blood pressure regulation

Details Peptides affecting blood pressure regulation Peptides affecting blood pressure regulation

1988-02-18

1988-09-20

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Angiotensin; related peptides

C07K 714

Patent

active

047726849

ABSTRACT:
Peptides of the formula: ##STR1## wherein: NH is the .alpha. amino group of amino acid AA.sup.1 ; ##STR2## is the carbonyl group of amino acid AA.sup.7 ; X is H--, ##STR3## GLU-VAL-, or VAL-TYR-HIS-GLU-VAL; Y is --OH, --NH.sub.2, or --PRO; AA.sup.1 is LYS, GLU, GLN, pGLU, .beta.ALA, PRO, PRO-OH, PIC, or AIB; AA.sup.2 is VAL, LEU, ILE, MET, or AIB; AA.sup.3 is ASP, TYR, GLU, HIS, or PHE; AA.sup.4 is VAL, MET, ILE, LEU, or AIB; AA.sup.5 is TYR, HIS, or GLU; AA.sup.6 is ALA, PRO, SER, .beta.ALA, PRO-OH, or AIB; and AA.sup.7 is VAL, LEU, ILE, or AIB;
and salts thereof are claimed as effective blood pressure regulators. Further provided, are antibodies to these peptides, as well as diagnostic and therapeutic methods for blood pressure regulation.

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