Peptides acting as both GLP-1 receptor agonists and glucagon...

Details Peptides acting as both GLP-1 receptor agonists and glucagon... Peptides acting as both GLP-1 receptor agonists and glucagon...

2005-08-26

2009-02-10

Kaushal, Sumesh (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S003100, C530S300000, C530S303000, C530S308000, C530S324000

Reexamination Certificate

active

07488715

ABSTRACT:
The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

REFERENCES:
patent: 6232310 (2001-05-01), Hansen et al.
patent: 7041646 (2006-05-01), Pan et al.
patent: 9111457 (1991-08-01), None
Claus et al . J Endocrinol. 192(2):371-80, 2007.
Pan et al J Biol Chem. 281(18):12506-15, 2006.
Frezza et al, Dig Dis Sci. 52:643-649, 2007.
Combettes, Curr Opin Pharmacol. (6):598-605. 2006.
Bojanowska Med Sci Monit. 2005 (8):RA271-278, 2005.

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