Peptides

Details Peptides Peptides

1995-06-07

1998-11-17

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530328, 530384, A61K 3804, C07K 1600, C07K 1700, C07K 500

Patent

active

058376844

ABSTRACT:
Peptide reagents and compositions thereof which reduce blood clotting initiated by the ternary complex of tissue factor (TF), FVIIa and FXa. The peptides have the amino acid sequences Thr--Leu--Tyr--Tyr--Trp--Arg--Ala--Ser--Ser--Thr (SEQ. ID. NO: 3) and Ile--Ile--Thr--Tyr--Arg--Lys--Gly--Ser--Ser--Thr (SEQ. ID. NO: 2).

REFERENCES:
patent: 5110730 (1992-05-01), Edgington et al.
Y. Nemerson, Blood, vol. 71, No. 1, 1988, pp. 1-8.
Gailani and Broze et al, Science 253, pp. 909-912.
Weiss et al, vol. 73, No. 4, Blood, 1989, pp. 968-975.
Furie B. and Furie, B.C. The New England Journal of Medicine, vol. 326, 800, 1992.

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