Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1994-06-28
1997-02-04
Gitomer, Ralph
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 24, 435 18, 435 723, 435 71, 435 4, 4241851, 530322, 530300, C12Q 137, C12Q 134, A61K 3814
Patent
active
055996868
ABSTRACT:
Assays which comprise oligopeptides and which are useful for determining free PSA protease activity in vitro and in vivo are described. Such oligopeptides comprise amino acid sequences that are recognized and proteolytically cleaved by free prostrate specific antigen (PSA). Also described are assays useful in identifying inhibitors of free PSA.
REFERENCES:
patent: 4277466 (1981-07-01), Trouet
patent: 4296105 (1981-10-01), Baurain et al.
patent: 4388305 (1983-06-01), Trouet et al.
patent: 4446122 (1984-05-01), Chu et al.
patent: 4828831 (1989-05-01), Hannart et al.
patent: 5024835 (1991-06-01), Rao et al.
patent: 5030620 (1991-07-01), Hannart et al.
patent: 5116615 (1992-05-01), Gokeen et al.
patent: 5227471 (1993-07-01), Wright, Jr.
patent: 5288612 (1994-02-01), Griffin et al.
patent: 5314996 (1994-05-01), Wright, Jr.
patent: 5332669 (1994-07-01), Devel
patent: 5349066 (1994-09-01), Kaneko et al.
patent: 5391723 (1995-02-01), Priest
Trail, P. A. et al., Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates, Science, vol. 261, pp. 212-215 (1993).
Willner, D. et al., (6-Maleimidocaproyl)hydrazone of Doxorubicin--A New Derivative for the Preparation of Immunoconjugates of Doxorubicin, Bioconjugate Chem., vol. 4, pp. 521-527 (1993).
Yu, H. et al., Immunoreactive Prostate-Specific Antigen Levels in Female and Male Breast Tumors and its Association with Steroid Hormone Receptors and Patient Age, Clinical Biochemistry, vol. 27, pp. 75-79 (1994).
Lilja, H. and Lundwall, A., "Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein," Proc. Natl. Acad, Sci. USA, Biochemistry, vol. 89, pp. 4559-4563 (1992).
Lilja, H., et al., "Semenogelin, the Predominant Protein in Human Semen," The Jour. of Biol. Chem., vol. 264, No. 3, pp. 1894-1900 (1989).
Christensson et al, "Eur. J. Biochem", vol. 194, pp. 755-763, 1990.
Watt et al, "Proc. Natl. Acad. Sci.", vol. 83, pp. 3166-3170, 1986.
DeFeo-Jones Deborah
Garsky Victor M.
Jones Raymond E.
Oliff Allen I.
Daniel Mark R.
Gitomer Ralph
Leary Louise
Merck & Co. , Inc.
Muthard David A.
LandOfFree
Peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-677567