Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides containing saccharide radicals – e.g. – bleomycins – etc.
Patent
1995-06-06
2000-11-07
Jones, Dwayne C.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides containing saccharide radicals, e.g., bleomycins, etc.
530324, 530326, 530328, 530329, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, A61K 3814, C07K 900
Patent
active
061438642
ABSTRACT:
Oligopeptides which comprise amino acid sequences that are recognized and proteolytically cleaved by free prostate specific antigen (PSA) are described. Also described are assays which comprise such oligopeptides useful for determining free PSA protease activity in vitro and in vivo. Therapeutic agents which comprise conjugates of such oligopeptides and known cytotoxic agents are also described.
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DeFeo-Jones Deborah
Feng Dong-Mei
Garsky Victor M.
Jones Raymond E.
Oliff Allen I.
Daniel Mark R.
Delacroix-Muirhead C.
Jones Dwayne C.
Merck & Co. , Inc.
Muthard David A.
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