Peptides

Details Peptides Peptides

1977-03-16

1978-07-11

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

041001524

ABSTRACT:
A novel peptide of the formula: ##STR1## wherein A is hydrogen, alkyl, aralkyl, alkoxyalkyl, hydroxyalkyl or alkoxy; R is ##STR2## X is --S-- or --(CH.sub.2).sub.n -- where n is 1 or 2 has a weaker TRH releasing activity than TRH and a stronger anaesthesia-antagonistic activity, spontaneous movement-stimulant activity or dopamine-potentiating activity than TRH.

REFERENCES:
patent: 3753969 (1973-05-01), Folkers et al.
patent: 3821188 (1974-06-01), McKinley et al.
patent: 3959248 (1976-05-01), Veber et al.
Bowers et al., Biochem. Biophys. Res. Comm., vol. 40, pp. 683-691 (1970).
Chang et al., J. Med. Chem., vol. 14, pp. 484-487, (1971).

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