Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-05-02
2006-05-02
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C530S350000
Reexamination Certificate
active
07037502
ABSTRACT:
The present invention provides novel anti-inflammatory peptides having the amino acid of the SEQ ID NO:1(KVLDPVKG); SEQ ID NO:2(KVLDGQDP) or SEQ ID No:3(DPVKG) containing inhibitory effects of transglutaminase and phospholipase A2, their derivatives, pharmaceutical compositions containing the aforesaid peptides, and methods for preventing inflammation by using the same. The peptides, derivatives thereof, analogs thereof and the pharmaceutical compositions containing the same of the present invention show the higher anti-inflammatory activities than the existing known peptides or steroidal anti-inflammatory drugs, such as dexamethasone.
REFERENCES:
Mikayama et al. PNAS, 1993. 90: 10056-10060.
Burgess et al J Cell Biol. 111:2129-2138, 1990.
Lazar et al. Mol Cell Biol. 8:1247-1252, 1988.
Whisstock et al Quarterly Review of Biophysics, 2003, 36, pp307-340.
Kim Soo-Youl
Sohn Joon-Hong
Barlow Josephs & Holmes, Ltd.
Belyavskyi Michail A.
Chan Christina
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