Peptide with anti-metastasis activity

Details Peptide with anti-metastasis activity Peptide with anti-metastasis activity

1989-05-10

1991-08-13

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, A61K 3702, C07K 706

Patent

active

050396625

ABSTRACT:
The invention discloses an acylated pentapeptide that inhibits metastasis activity of malignant cells.

REFERENCES:
L. Furcht et al., "Peptide Fragments of Fibronectin and Laminin: Role in Cell Adhesion and Inhibition of Experimental Tumor Metastasis", Development Oncology 41:43 (1986).
L. T. Furcht et al., "Peptide Fragments of Laminin and Fibronectin Promote Migration (Haptotaxis and Chemotaxis) of Metastatic Cells", CIBA Foundation Symposium 108:130 (1984).
J. Graf et al., "Identification of an Amino Acid Sequence in Laminin Mediating Cell Attachment, Chemotaxis, and Receptor Binding", Cell 48:989 (1987).
Yukihide Iwamoto et al., "YIGSR, A Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation", Science 238, 1132-1134 (1987).
Makoto Sasaki et al., "Sequence of the cDNA Encoding the Laminin B1 Chain Reveals a Multidomain Protein Containing Cysteine-Rich Repeats", Proc. Natl. Acad. Sci., USA 84:935 (1987).
Jeannette Graf et al., "A Pentapeptide from the Laminin B1 Chain Mediates Cell Adhesion and Binds the 67000 Laminin Receptor", Biochemistry 26:6896 (1987).

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