Peptide which binds SH.sub.2 domains of protein tyrosine phospha

Details Peptide which binds SH.sub.2 domains of protein tyrosine phospha Peptide which binds SH.sub.2 domains of protein tyrosine phospha

1995-03-10

1997-08-19

Green, Lora M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530300, 530350, 530352, 530327, 530399, 530345, A61K 3804

Patent

active

056590121

ABSTRACT:
Novel assays for identifying agents which alter the effect of erythropoietin on proliferation of erythroid cells and agents identified thereby. Novel peptide comprising the erythropoietin receptor binding site for SH-PTP1.

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patent: 5378808 (1995-01-01), D'Andrea et al.
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Argetsinger, Lawrence S., et al., "Identification of JAK2 As a Growth Hormone Receptor-Associated Tyrosine Kinase," Cell 74:237-244 (1993).
Pei, Dehua, et al., "Intramolecular Regulation of Protein Tyrosine Phosphatase SH-PTP1: A New Function for Src Homology 2 Domains," Biochemistry 33(51):15483-15493 (1994).
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Shen, Shi-Hsiang, et al., "A Protein-Tyrosine Phosphatase with Sequence Similarity to the SH2 Domain of the Protein-Tyrosine Kinases," Nature 352:736-739 (1991).
Silvennoinen, Olli, et al., "Structure of the Murine Jak2 Protein-Tyrosine Kinase and Its Role in Interleukin 3 Signal Transduction," Proc. Natl. Acad. Sci. USA 90:8429-8433 (1993).
Sugimoto, Seiji, et al., "Activation of the SH2-Containing Protein Tyrosine Phosphatase, SH-PTP2, by Phosphotyrosine-Containing Peptides Derived from Insulin Receptor Substrate-1," J. Biologic. Chemistry 269(18):13614-13622 (1994).
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Yi, Taolin, et al., "Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor .beta. Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis," Mol. Cell. Biol. 13(12):7577-7586 (1993).

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