Peptide (VIRIP) which inhibits a circulating virus in humans...

Details Peptide (VIRIP) which inhibits a circulating virus in humans... Peptide (VIRIP) which inhibits a circulating virus in humans...

2006-05-02

2006-05-02

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S007600, C514S008100, C530S300000, C530S326000

Reexamination Certificate

active

07037896

ABSTRACT:
A peptide having the following amino acid sequence:in-line-formulae description="In-line Formulae" end="lead"?Z1-LEAIPMSIPPEVKFNKPFVF-Z2(VIRIP)in-line-formulae description="In-line Formulae" end="tail"?and its biologically active fragments and/or variants and/or derivatives, especially amidated, acetylated, sulfated, polyethylene glycol (PEG) modified, phosphorylated and/or glycosylated derivatives, and peptides obtainable by multiple synthesis which have the biological activity of VIRIP;wherein Z1and Z2are independently a sequence of from 0 to 10 amino acid residues, and if Z1or Z2=zero amino acid residues, then Z1=H and/or Z2=COOH.

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Shapiro et al.,“Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1”, FASEB Journal, vol. 15, 122, Jan. 2001, pp. 115-122.

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